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Heres the interesting part - ketamine actually reduces the functional activity in the DMN

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Based on mechanism, several groups warrant extra caution: Pregnant or breastfeeding people, because no developmental data exist

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"People who really believe that that's the power of placebo." B12 has me like —@katyperry As a geriatrician at Mount Sinai Hospital in Toronto, Sinha said he commonly tests for B12 levels in patients "when we're assessing a person for dementia or a person with balance issues." Otherwise he said it's ineffective to take B12 supplements to prevent deficiency and there are even potential risks of over-doing it

10.1016/S0959-8049(02)00020-5 52 DohrmanA.MiyataS.GallupM.LiJ.-D.ChapelinC.CosteA.et al (1998)